U. S. Highway 78

Charleston, South Carolina – Memphis, Tennessee
Longest Mileage: 736
Current Mileage: 638

U.S. 78 is one of the original 1926 highways. Its current east to west route takes it through 5 states.

  • South Carolina – 143 Miles
  • Georgia – 203 Miles
  • Alabama – 160 Miles
  • Mississippi – 122 Miles
  • Tennessee – 10 Miles