U. S. Highway 21

Wytheville, Virginia – Huntington Island State Park, SC
Longest mileage: 843
Current Mileage: 371

 

U.S. 21 is one of the original 1926 highways. It once traveled in Ohio and West Virginia. The current north to south route through 3 states has been in place since 1978.

  • Ohio – Decommissioned
  • West Virginia – Decommissioned
  • Virginia – 35 Miles
  • North Carolina – 122 Miles
  • South Carolina – 214 Miles